GRIK3 rs490647 is a Common Genetic Variant between Personality and Subjective Well-being in Chinese Han Population

Lin An; Chuanxin Liu; Naixin Zhang; Zhixuan Chen; Decheng Ren; Fan Yuan; Ruixue Yuan; Yan Bi; Lei Ji; Zhenming Guo; Gaini Ma; Fei Xu; Fengping Yang; Liping Zhu; Gabriel Robert; Yifeng Xu; Lin He; Bo Bai; Tao Yu; Guang He

doi:10.28991/esj-2019-01171

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Lin An Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Chuanxin Liu School of Mental Health, Jining Medical University, 16 Hehua Rd, Taibaihu New District, Jining, Shandong 272067,, China
Naixin Zhang Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Zhixuan Chen Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Decheng Ren Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Fan Yuan Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Ruixue Yuan Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Yan Bi Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Lei Ji Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Zhenming Guo Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Gaini Ma Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Fei Xu Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Fengping Yang Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Liping Zhu Shanghai Center for Women and Children's Health, 339 Luding Road, Shanghai 200062,, China
Gabriel Robert Department of psychiatry, EA4712 Behavior and Basal Ganglia Unit, Medical University of Rennes, 1 Rennes,, France
Yifeng Xu Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030,, China
Lin He Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China
Bo Bai Institute of Neurobiology, Jining Medical University, 16 Hehua Rd, Taibaihu New District, Jining, Shandong 272067,, China
Tao Yu Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China School of Mental Health, Jining Medical University, 16 Hehua Rd, Taibaihu New District, Jining, Shandong 272067, China Shanghai Center for Women and Children's Health, 339 Luding Road, Shanghai 200062, China, China
Guang He
heguangbiox@163.com
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China, China

Vol. 3 No. 2 (2019): April

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Personality and subjective well-being (SWB) have been suggested to be strongly related in previous studies. This study was intended to confirm the relationship between personality and SWB and tried to seek out the genetic variants which underlie both personality and SWB. The subjects were 890 participants from Chinese Han population. We evaluated their personality using the Big Five Inventory (BFI) and used the Satisfaction With Life Scale (SWLS) to reflect their SWB. Five single nucleotide polymorphisms (SNPs) were selected from the literature (rs1426371, rs2164273, rs322931, rs3756290, rs490647) and genotyped for genetic association study. We found negative correlations between neuroticism and SWB. On the contrary, extraversion and agreeableness were positively associated with SWB. Three SNPs (rs2164273, rs3756290, rs490647) out of the five were found to connect with personality (extraversion, neuroticism, conscientiousness and openness to experience) and rs490647 variants of GRIK3 was also associated with SWB. Individuals carrying G allele at this site were predisposed to have lower risk to be neuroticism and greater chance to be extraverted, open and satisfied with their life. In summary, our study revealed that rs490647 might be a good candidate genetic variant for personality and SWB in Chinese Han population.

An, L., Liu, C., Zhang, N., Chen, Z., Ren, D., Yuan, F., … He, G. (2019). GRIK3 rs490647 is a Common Genetic Variant between Personality and Subjective Well-being in Chinese Han Population. Emerging Science Journal, 3(2), 78–87. https://doi.org/10.28991/esj-2019-01171

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McCrae, Robert R., and Oliver P. John. "An Introduction to the Five-Factor Model and Its Applications.” Journal of Personality 60, no. 2 (June 1992): 175–215. doi:10.1111/j.1467-6494.1992.tb00970.x.

Goldberg, Lewis R. "An Alternative ‘Description of Personality': The Big-Five Factor Structure.” Journal of Personality and Social Psychology 59, no. 6 (1990): 1216–1229. doi:10.1037/0022-3514.59.6.1216.

Diener, Ed, Shigehiro Oishi, and Richard E. Lucas. "Personality, Culture, and Subjective Well-Being: Emotional and Cognitive Evaluations of Life.” Annual Review of Psychology 54, no. 1 (February 2003): 403–425. doi:10.1146/annurev.psych.54. 101601.145056.

Diener, Ed, Eunkook M. Suh, Richard E. Lucas, and Heidi L. Smith. "Subjective Well-Being: Three Decades of Progress.” Psychological Bulletin 125, no. 2 (1999): 276–302. doi:10.1037/0033-2909.125.2.276.

Bartels, Meike, and Dorret I. Boomsma. "Born to Be Happy? The Etiology of Subjective Well-Being.” Behavior Genetics 39, no. 6 (September 3, 2009): 605–615. doi:10.1007/s10519-009-9294-8.

Rietveld, C. A., D. Cesarini, D. J. Benjamin, P. D. Koellinger, J.-E. De Neve, H. Tiemeier, M. Johannesson, et al. "Molecular Genetics and Subjective Well-Being.” Proceedings of the National Academy of Sciences 110, no. 24 (May 24, 2013): 9692–9697. doi:10.1073/pnas.1222171110.

Diener, Ed, Robert A. Emmons, Randy J. Larsen, and Sharon Griffin. "The Satisfaction With Life Scale.” Journal of Personality Assessment 49, no. 1 (February 1985): 71–75. doi:10.1207/s15327752jpa4901_13.

Costa, Paul T., and Robert R. McCrae. "Influence of Extraversion and Neuroticism on Subjective Well-Being: Happy and Unhappy People.” Journal of Personality and Social Psychology 38, no. 4 (1980): 668–678. doi:10.1037/0022-3514.38.4.668.

E., Richard, and Ed Diener. "Personality and Subjective Well-Being.” The Science of Well-Being (2009): 75–102. doi:10.1007/978-90-481-2350-6_4.

Weiss, Alexander, Timothy C. Bates, and Michelle Luciano. "Happiness Is a Personal(ity) Thing.” Psychological Science 19, no. 3 (March 2008): 205–210. doi:10.1111/j.1467-9280.2008.02068.x.

Schimmack, Ulrich, Phanikiran Radhakrishnan, Shigehiro Oishi, Vivian Dzokoto, and Stephan Ahadi. "Culture, Personality, and Subjective Well-Being: Integrating Process Models of Life Satisfaction.” Journal of Personality and Social Psychology 82, no. 4 (2002): 582–593. doi:10.1037/0022-3514.82.4.582.

Schimmack, Ulrich, Ed Diener, and Shigehiro Oishi. "Life-Satisfaction Is a Momentary Judgment and a Stable Personality Characteristic: The Use of Chronically Accessible and Stable Sources.” Journal of Personality 70, no. 3 (June 2002): 345–384. doi:10.1111/1467-6494.05008.

Tanksale, Deepa. "Big Five Personality Traits: Are They Really Important for the Subjective Well-Being of Indians?” International Journal of Psychology 50, no. 1 (March 27, 2014): 64–69. doi:10.1002/ijop.12060.

Otonari, Jun, Jun Nagano, Makiko Morita, Sanjeev Budhathoki, Naotaka Tashiro, Kengo Toyomura, Suminori Kono, Kazue Imai, Keizo Ohnaka, and Ryoichi Takayanagi. "Neuroticism and Extraversion Personality Traits, Health Behaviours, and Subjective Well-Being: The Fukuoka Study (Japan).” Quality of Life Research 21, no. 10 (December 29, 2011): 1847–1855. doi:10.1007/s11136-011-0098-y.

Ha, Shang E., and Seokho Kim. "Personality and Subjective Well-Being: Evidence from South Korea.” Social Indicators Research 111, no. 1 (February 18, 2012): 341–359. doi:10.1007/s11205-012-0009-9.

Zhai, Qingguo, Mike Willis, Bob O'Shea, Yubo Zhai, and Yuwen Yang. "Big Five Personality Traits, Job Satisfaction and Subjective Wellbeing in China.” International Journal of Psychology 48, no. 6 (December 2013): 1099–1108. doi:10.1080/00207594.2012.732700.

Vukasovič, Tena, and Denis Bratko. "Heritability of Personality: A Meta-Analysis of Behavior Genetic Studies.” Psychological Bulletin 141, no. 4 (2015): 769–785. doi:10.1037/bul0000017.

Bouchard, Thomas J. "Genes, environment, and personality." Science-AAAS-Weekly Paper Edition 264, no. 5166 (1994): 1700-1701.

Kim, Han-Na, Seung-Ju Roh, Yeon Ah Sung, Hye Won Chung, Jong-Young Lee, Juhee Cho, Hocheol Shin, and Hyung-Lae Kim. "Erratum: Genome-Wide Association Study of the Five-Factor Model of Personality in Young Korean Women.” Journal of Human Genetics 60, no. 8 (August 2015): 463–463. doi:10.1038/jhg.2015.67.

De Moor, Marleen H. M., Stéphanie M. van den Berg, Karin J. H. Verweij, Robert F. Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K. Matteson, et al. "Meta-Analysis of Genome-Wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.” JAMA Psychiatry 72, no. 7 (July 1, 2015): 642. doi:10.1001/jamapsychiatry.2015.0554.

De Moor, M H M, P T Costa, A Terracciano, R F Krueger, E J C de Geus, T Toshiko, B W J H Penninx, et al. "Meta-Analysis of Genome-Wide Association Studies for Personality.” Molecular Psychiatry 17, no. 3 (December 21, 2010): 337–349. doi:10.1038/mp.2010.128.

Smith, D J, V Escott-Price, G Davies, M E S Bailey, L Colodro-Conde, J Ward, A Vedernikov, et al. "Erratum: Genome-Wide Analysis of over 106 000 Individuals Identifies 9 Neuroticism-Associated Loci.” Molecular Psychiatry 21, no. 11 (September 13, 2016): 1644–1644. doi:10.1038/mp.2016.177.

Okbay, Aysu, Bart M L Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, et al. "Genetic Variants Associated with Subjective Well-Being, Depressive Symptoms and Neuroticism Identified through Genome-Wide Analyses.” Nature Genetics 48, no. 6 (April 18, 2016): 624–633. doi:10.1038/ng.3552.

Lo, Min-Tzu, David A Hinds, Joyce Y Tung, Carol Franz, Chun-Chieh Fan, Yunpeng Wang, Olav B Smeland, et al. "Genome-Wide Analyses for Personality Traits Identify Six Genomic Loci and Show Correlations with Psychiatric Disorders.” Nature Genetics 49, no. 1 (December 5, 2016): 152–156. doi:10.1038/ng.3736.

D.T. Lykken, T.J. Bouchard, Jr., M. McGue, A. Tellegen. "The Minnesota Twin Family Registry: some initial findings.” Acta Genet Med Gemellol (Roma) 39, no.1 1990): 35-70.

NES, R. B., E. Rí¸ysamb, K. Tambs, J. R. Harris, and T. Reichborn-Kjennerud. "Subjective Well-Being: Genetic and Environmental Contributions to Stability and Change.” Psychological Medicine 36, no. 07 (March 30, 2006): 1033. doi:10.1017/s0033291706007409.

Stubbe, J. H., D. Posthuma, D. I. Boomsma, and E. J. C. De Geus. "Heritability of Life Satisfaction in Adults: a Twin-Family Study.” Psychological Medicine 35, no. 11 (June 29, 2005): 1581. doi:10.1017/s0033291705005374.

Feldman, Ruth, Mikhail Monakhov, Maayan Pratt, and Richard P. Ebstein. "Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology.” Biological Psychiatry 79, no. 3 (February 2016): 174–184. doi:10.1016/j.biopsych.2015.08.008.

Jia, Tianye, Christine Macare, Sylvane Desrivières, Dante A. Gonzalez, Chenyang Tao, Xiaoxi Ji, Barbara Ruggeri, et al. "Neural Basis of Reward Anticipation and Its Genetic Determinants.” Proceedings of the National Academy of Sciences 113, no. 14 (March 21, 2016): 3879–3884. doi:10.1073/pnas.1503252113.

Wingo, A P, L M Almli, J S Stevens, T Jovanovic, T S Wingo, G Tharp, Y Li, et al. "Genome-Wide Association Study of Positive Emotion Identifies a Genetic Variant and a Role for microRNAs.” Molecular Psychiatry 22, no. 5 (September 6, 2016): 774–783. doi:10.1038/mp.2016.143.

John, Oliver P., and Sanjay Srivastava. "The Big Five trait taxonomy: History, measurement, and theoretical perspectives." Handbook of personality: Theory and research 2, no. 1999 (1999): 102-138.

Shen, Jiawei, Zhiqiang Li, Jianhua Chen, Zhijian Song, Zhaowei Zhou, and Yongyong Shi. "SHEsisPlus, a Toolset for Genetic Studies on Polyploid Species.” Scientific Reports 6, no. 1 (April 6, 2016). doi:10.1038/srep24095.

Zhang, Liwei. "Prediction of Chinese Life Satisfaction: Contribution of Collective Self"esteem.” International Journal of Psychology 40, no. 3 (June 2005): 189–200. doi:10.1080/00207590444000285.

Weiss, Alexander, Bart M. L. Baselmans, Edith Hofer, Jingyun Yang, Aysu Okbay, Penelope A. Lind, Mike B. Miller, et al. "Personality Polygenes, Positive Affect, and Life Satisfaction.” Twin Research and Human Genetics 19, no. 05 (August 22, 2016): 407–417. doi:10.1017/thg.2016.65.

DeNeve, Kristina M., and Harris Cooper. "The Happy Personality: A Meta-Analysis of 137 Personality Traits and Subjective Well-Being.” Psychological Bulletin 124, no. 2 (1998): 197–229. doi:10.1037/0033-2909.124.2.197.

Schiffer, Hans H., Geoffrey T. Swanson, Elizier Masliah, and Stephen F. Heinemann. "Unequal Expression of Allelic Kainate Receptor GluR7 mRNAs in Human Brains.” The Journal of Neuroscience 20, no. 24 (December 15, 2000): 9025–9033. doi:10.1523/jneurosci.20-24-09025.2000.

Bortolotto, Zuner A., Vernon R. J. Clarke, Caroline M. Delany, Michael C. Parry, Ilse Smolders, Michel Vignes, Ken H. Ho, et al. "Kainate Receptors Are Involved in Synaptic Plasticity.” Nature 402, no. 6759 (November 1999): 297–301. doi:10.1038/46290.

Ohi, Kazutaka, Takamitsu Shimada, Toshiki Yasuyama, Kohei Kimura, Takashi Uehara, and Yasuhiro Kawasaki. "Spatial and Temporal Expression Patterns of Genes Around Nine Neuroticism-Associated Loci.” Progress in Neuro-Psychopharmacology and Biological Psychiatry 77 (July 2017): 164–171. doi:10.1016/j.pnpbp.2017.04.019.

Pinheiro, P. S., D. Perrais, F. Coussen, J. Barhanin, B. Bettler, J. R. Mann, J. O. Malva, S. F. Heinemann, and C. Mulle. "GluR7 Is an Essential Subunit of Presynaptic Kainate Autoreceptors at Hippocampal Mossy Fiber Synapses.” Proceedings of the National Academy of Sciences 104, no. 29 (July 9, 2007): 12181–12186. doi:10.1073/pnas.0608891104.

Epstein, Franklin H., Stuart A. Lipton, and Paul A. Rosenberg. "Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders.” New England Journal of Medicine 330, no. 9 (March 3, 1994): 613–622. doi:10.1056/nejm199403033300907.

DeLisi, Lynn E., Andrea Mesen, Carlos Rodriguez, Arturo Bertheau, Beatrice LaPrade, Michelle Llach, Silvina Riondet, et al. "Genome-Wide Scan for Linkage to Schizophrenia in a Spanish-Origin Cohort from Costa Rica.” American Journal of Medical Genetics 114, no. 5 (June 11, 2002): 497–508. doi:10.1002/ajmg.10538.

Begni, S, M Popoli, S Moraschi, S Bignotti, G B Tura, and M Gennarelli. "Association Between the Ionotropic Glutamate Receptor Kainate 3 (GRIK3) Ser310ala Polymorphism and Schizophrenia.” Molecular Psychiatry 7, no. 4 (April 2002): 416–418. doi:10.1038/sj.mp.4000987.

Gray, A L, T M Hyde, A Deep-Soboslay, J E Kleinman, and M S Sodhi. "Sex Differences in Glutamate Receptor Gene Expression in Major Depression and Suicide.” Molecular Psychiatry 20, no. 9 (July 14, 2015): 1057–1068. doi:10.1038/mp.2015.91.

Schiffer, H.H., and S.F. Heinemann. "Association of the Human Kainate receptorGluR7 Gene (GRIK3) with Recurrent Major Depressive Disorder.” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B, no. 1 (2006): 20–26. doi:10.1002/ajmg.b.30374.

Minelli, Alessandra, Catia Scassellati, Cristian Bonvicini, Jorge Perez, and Massimo Gennarelli. "An Association of GRIK3 Ser310Ala Functional Polymorphism with Personality Traits.” Neuropsychobiology 59, no. 1 (2009): 28–33. doi:10.1159/000202827.

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GRIK3 rs490647 is a Common Genetic Variant between Personality and Subjective Well-being in Chinese Han Population

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GRIK3 rs490647 is a Common Genetic Variant between Personality and Subjective Well-being in Chinese Han Population

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Digital Transformation: Opportunities and Challenges for Leaders in the Emerging Countries in Response to Covid-19 Pandemic

Thermal Regeneration and Reuse of Carbon and Glass Fibers from Waste Composites

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