Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)

Tati Suhartati; Khalimatus Sa'diah; Yandri Yandri; Sutopo Hadi

doi:10.28991/ESJ-2023-07-03-05

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Tati Suhartati
tati.suhartati@fmipa.unila.ac.id
Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Lampung, Lampung 35145,, Indonesia https://orcid.org/0000-0002-9398-1965
Khalimatus Sa'diah Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Lampung, Lampung 35145,, Indonesia
Yandri Yandri Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Lampung, Lampung 35145,, Indonesia
Sutopo Hadi Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Lampung, Lampung 35145,, Indonesia

Vol. 7 No. 3 (2023): June

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This research is a continuation of the successful isolation of artocarpin from the root of Artocarpus kemando Miq reported in our previous study. In the previous study, the artocarpin was characterized with UV-Vis and FTIR techniques. In this follow-up investigation, the artocarpin was subjected to a transesterification reaction using acetic anhydride and pyridine as catalysts, and the product of the reaction was specified as compound 1. The compound 1 was further characterized with different techniques to gain more complete data and then tested for anticancer activity test against P-388 murine leukemia cells. Characterizations of the compound 1 using ¹H-NMR and ¹³C-NMR techniques suggest that the modification reaction resulted in the conversion of the -OH groups at C2' and 4' at the artocarpin molecule to -OOCH₃, and based on the MS analysis, the compound was proposed to have the molecular formula of C₃₀H₃₂O₈. Another important feature of compound 1 that should be noted is the significant improvement in stability compared to the unmodified artocarpin. Anticancer activity tests against P-388 murine leukemia cells revealed that compound 1 has an IC₅₀of 2.35 µg/mL, confirming that the compound is categorized as an active anticancer agent and suggesting that the compound has promising potential that deserves further investigations.

Doi: 10.28991/ESJ-2023-07-03-05

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Suhartati, T., Sa’diah, K., Yandri, Y., & Hadi, S. (2023). Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.). Emerging Science Journal, 7(3), 733–743. https://doi.org/10.28991/ESJ-2023-07-03-05

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Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)

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Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)

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